The Origin and Structure of a Fibrous Tissue Formed in Wound Healing

1. In experimental wounds, made by removing various sized pieces of skin from the frog, there is a rapid coagulation of the blood plasma and lymph to form a coagulation tissue which fills the wound cavity. 2. The observations on the living animals show that the coagulation a grave intoxication, but a low reading may be observed in some fatal cases and gives no assurance that a fatal intoxication may not supervene. The kidneys in practically all these experiments are normal in all respects. It is possible that protein or tissue destruction rather than impaired eliminative function is responsible for the rise in non-coagulable nitrogen of the blood in these acute intoxications. Transfusions of dextrose solutions often benefit intestinal obstruction, and may depress the level of the non-coagulable nitrogen in the blood. Some cases show no change in non-coagulable nitrogen following transfusions and diuresis, and, as a rule, such cases present the most severe intoxication.